2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140904
    Biotin-PEG12-TFP ester
    Biotin-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG12-TFP ester
  • HY-138739
    Azido-PEG10-propargyl
    Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG10-propargyl
  • HY-W096077
    Benzyl-PEG7-amine 868594-43-8
    Benzyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG7-amine
  • HY-145246
    Biotin-PEG8-Vidarabine
    Biotin-PEG8-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses.
    Biotin-PEG8-Vidarabine
  • HY-126717
    SPDP-PEG6-NHS ester 1818294-32-4
    SPDP-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    SPDP-PEG6-NHS ester
  • HY-141090
    Carboxyrhodamine 110-PEG3-Azide 1536327-95-3
    Carboxyrhodamine 110-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Carboxyrhodamine 110-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Carboxyrhodamine 110-PEG3-Azide
  • HY-138713
    Benzyl-PEG10-Ots
    Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG10-Ots
  • HY-133469
    Methyltetrazine-PEG8-N3
    Methyltetrazine-PEG8-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Methyltetrazine-PEG8-N3
  • HY-140280
    DBCO-PEG1 1839049-33-0
    DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG1
  • HY-W190901
    Amino-PEG11-acid 1616426-12-0
    Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG11-acid
  • HY-140263
    NH-bis(m-PEG4) 123852-08-4
    NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(m-PEG4)
  • HY-133356
    Boc-NH-PEG15-azide
    Boc-NH-PEG15-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG15-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG15-azide
  • HY-140287
    DBCO-C2-PEG4-amine
    DBCO-C2-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-C2-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-C2-PEG4-amine
  • HY-132013
    Benzyl-PEG8-amine
    Benzyl-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-amine
  • HY-140996
    Bis-Mal-PEG19
    Bis-Mal-PEG19 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Mal-PEG19
  • HY-140200
    Amino-PEG36-Boc
    Amino-PEG36-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG36-Boc
  • HY-138706
    Azido-PEG8-azide 361543-07-9 98.20%
    Azido-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-azide
  • HY-138528
    Thiol-C9-PEG5-acid
    Thiol-C9-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C9-PEG5-acid
  • HY-140716
    HO-PEG-amine (MW 5000)
    HO-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG-amine (MW 5000)
  • HY-140006
    Diketone-PEG4-PFP ester 2353409-84-2
    Diketone-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diketone-PEG4-PFP ester
PROTAC Linkers Isoform Comparison

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